Trafficking in human beings (THB) and smuggling of migrants (SoM), two distinct but often interrelated phenomena, occur on a global scale. Searching for a way out of economic inequalities, environmental crises, armed conflict, political instability and persecution, and in view of tightening border controls and restricted options for legal migration, migrants are driven to seek the services of smugglers. At the same time, a globalized economy fosters demand for diverse types of exploitation, which also makes migrants vulnerable to traffickers. Both THB and SoM are billion-dollar businesses that exact high human costs. This is illustrated by the many migrants dying while being smuggled along increasingly dangerous migration routes, and by the millions of trafficking victims trapped in exploitative situations worldwide. The African, Caribbean and Pacific (ACP) Group of States are increasingly stepping up to address THB and SoM. However, they face challenges in developing the necessary holistic, long-term interventions that combine law enforcement with a rights-based, victim-centred approach and with prevention efforts that are linked to development and offer realistic, practical alternatives to irregular migration. This ACP-EU Migration Action publication analyses these challenges and provides recommendations to tackle the difficulties that ACP countries face in relation to THB and SoM.