Despite increased U.S. foreign policy attention over the past decade, human trafficking remains widespread and deeply entrenched in many Asian countries. The precise number of people being trafficked is difficult to estimate, but new studies suggest nearly 36 million victims worldwide. Of those 36 million, nearly two-thirds are from Asia. Total profits from worldwide forced labor and sex trafficking could be as high as $150 billion annually. The U.S. has a national security interest and vital role to play in shaping effective anti–human trafficking policy in Asia. The U.S. should model positive anti-trafficking policies within its own borders and capitalize on its partnerships in Asia to reduce and eventually end human trafficking. Engaging more closely with Asian countries on human trafficking problems would strengthen U.S. economic and humanitarian involvement in the region and bolster democratic governance by promoting individual liberty and human rights.